Germany has emerged as one of Europe’s most important digital health markets. With annual healthcare spending of €495 billion, the country’s digital health segment was worth $8.2 billion in 2023 and is projected to grow to more than $22 billion by 2030.
A key driver is the Digital Healthcare Act (DVG) and the Digital Health Applications (DiGA pathway), which makes certified health apps reimbursable by statutory insurers. Nearly 60 apps are already prescribable, making Germany one of the first countries to fully integrate digital therapeutics into mainstream care.
In 2025, the landscape spans AI platforms, specialist telemedicine clinics, and reimbursed digital therapeutics. Some companies are expanding internationally while others are scaling within Germany through insurer and hospital partnerships. The following startups represent those with clear traction — through funding, regulation, or clinical validation — and highlight why Germany is at the forefront of digital health innovation in Europe.
17 Notable Digital Health Startups in Germany 2025
Ada Health
Founded: 2011 | Location: Berlin | Category: AI symptom assessment
Ada Health operates one of the world’s leading AI-driven health assessment platforms. Its app uses a medical reasoning engine to guide users through symptom checks and recommend next steps, with the option to connect to a physician for follow-up care.
The company has raised a total of $167 million across five rounds, including a $90 million Series B in May 2021 led by Leaps by Bayer and Samsung Catalyst Fund, and a $30 million extension in February 2022 backed by Farallon Capital and Red River West.
Ada employs over 230 staff and reported annual revenue of about €7 million in 2021. Partnerships with global pharma and health providers illustrate its dual strategy: consumer access at scale, and integration into care pathways through insurers and health systems.
Wellster Healthtech Group
Founded: 2018 | Location: Munich | Category: Direct-to-patient telemedicine brands
Wellster Healthtech Group has built one of Germany’s largest multi-brand digital clinics, operating platforms such as GoSpring, MySummer, and GoLight. Its brands cover categories including men’s health, women’s health, weight management, and dermatology, offering patients discreet online consultations, prescriptions, and personalized treatment plans.
In 2021, Wellster raised €35 million in a Series B round, later extended to about $60 million in January 2022 with participation from Claret Capital and Mangrove Capital Partners. With this funding, Wellster is expanding its category coverage and scaling across European markets.
Cara Care (HiDoc Technologies)
Founded: 2016 | Location: Berlin | Category: Digestive digital therapeutics
Cara Care develops digital therapeutics for gastrointestinal health, combining app-based programs with clinician support. Its flagship product, Cara Care for IBS, became officially listed as a reimbursable DiGA (Digital Health Application) on January 1, 2022, making it prescribable and reimbursable by statutory health insurers across Germany.
The company raised a total of $16 million across three funding rounds, including $7 million Series A rounds in 2019 and 2022 with backing from investors such as Dr. Schär, Johnson & Johnson Innovation, and Asabys Partners. On March 12, 2024, Cara Care was acquired by U.S.-based Mahana Therapeutics, which is integrating the platform into its broader digital therapeutics portfolio.
AERA Health
Founded: 2022 | Location: Munich/Basel | Category: Preventive, data-driven care
AERA Health is building a preventive health platform that blends medical expertise with data-driven insights. Its programs aim to help individuals take proactive steps in areas like fitness, nutrition, and lifestyle by unifying fragmented health data into actionable guidance.
The company raised €4 million in a pre-seed round in March 2023, attracting prominent backers such as Jeff Wilke (former Amazon Worldwide Consumer CEO) and Bracken Darrell (CEO of Logitech at the time). With operations spanning Germany and Switzerland, AERA Health is positioning itself as a new category of preventive care provider in Europe.
XO Life
Founded: 2018 | Location: Munich/Berlin | Category: Patient-reported outcomes and support
XO Life focuses on capturing real-world patient experiences and outcomes through its platform, ImpactMonitor. The system enables patients to document symptoms, side effects, and quality-of-life metrics, providing valuable data to pharmaceutical companies, providers, and payers.
This information is increasingly used to shape digital patient support programs and inform post-market evidence generation. In August 2024, XO Life secured €7 million in funding led by Sandwater and Grazia Equity to expand internationally, building on earlier rounds of over €2 million.
Clue (BioWink GmbH)
Founded: 2012 | Location: Berlin | Category: Reproductive health / digital contraceptive
Clue offers one of the world’s most widely used menstrual and fertility tracking apps. In 2017, it raised a $20 million Series B led by Nokia Growth Partners, with participation from Union Square Ventures, Mosaic Ventures, and others, bringing its total funding at the time to about $30 million. The company has partnered with leading research institutions including Stanford, Columbia, and Oxford to strengthen its scientific base.
In 2021, Clue secured FDA clearance for Clue Birth Control, a digital contraceptive that uses a statistical model of cycle data to predict fertile and non-fertile days. With this clearance, Clue became one of the first Berlin-based femtech startups to bring a regulated contraceptive software product to the U.S. market. Clue illustrates how German startups can evolve from consumer health apps into regulated digital health tools with global reach.
Noah Labs GmbH
Founded: 2022 | Location: Berlin/Potsdam | Category: AI cardiovascular telemonitoring
Noah Labs develops AI-driven tools to support the monitoring and treatment of cardiovascular disease, with a focus on heart failure. Its Ark platform enables remote telemonitoring by combining voice biomarkers with clinical data to detect deterioration early.
In February 2025, the company raised a €3 million seed round led by Speedinvest and Nucleus Capital. It was also selected for the European Innovation Council (EIC) Accelerator, securing up to €11 million in blended financing to advance regulatory and market expansion.
Noah Labs reports its telemonitoring software has achieved MDR Class IIa certification and is being deployed in collaborations with Charité Berlin and the German Heart Center (DHZB).
HelloBetter
Founded: 2015 | Location: Berlin/Potsdam | Category: Digital mental health (multiple DiGAs)
HelloBetter is a pioneer in evidence-based digital mental health, offering cognitive behavioral therapy (CBT) programs for conditions such as depression, anxiety, and insomnia. Several of its products are officially listed as DiGAs, making them reimbursable by German statutory health insurers.
In March 2025, the company raised over €6 million (mix of cash and media-for-equity) led by Mutuelles Impact, with support from MMV, HealthCap, Expon, and DVH Ventures. This brings its total funding to about €31 million. Earlier, it also secured a €3 million non-dilutive grant to help build an AI-powered mental wellness solution. One priority for 2025 is expanding into the French market, including seeking reimbursement via France’s Haute Autorité de Santé (HAS).
HelloBetter’s evidence base is strong: it has published more than 30 randomized controlled trials and is positioning itself to combine clinical rigor with international reach.
Formel Skin
Founded: 2019 | Location: Berlin | Category: Digital dermatology clinic
Formel Skin delivers personalized dermatology care through an online platform that connects patients with licensed physicians. Users upload photos and receive tailored treatment plans, including prescription therapies, delivered directly to their homes.
The company raised a €30 million Series A round in early 2022, led by Singular and Heal Capital, making it one of the largest early-stage financings for a German healthtech startup. Its model combines the accessibility of telemedicine with the medical rigor of dermatologist oversight, addressing conditions such as acne, rosacea, and psoriasis.
Doctorly
Founded: 2018 | Location: Berlin | Category: Cloud practice operating system
Doctorly is rethinking practice management software by replacing legacy, on-premise systems with a fully cloud-based platform. Built for German medical practices, it integrates scheduling, electronic health records, billing, and patient communication into a single regulated solution.
In March 2023, Doctorly raised a $10 million Series A round led by Wellstreet and Horizons Ventures, later extending the round to about $17 million in November 2023. The company emphasizes its distinction as one of the first VC-backed providers approved to distribute practice management software in Germany’s tightly regulated market.
Routine Health GmbH
Founded: 2018 | Location: Düsseldorf | Category: Tele-ergotherapy for injury aftercare
Routine Health specializes in delivering remote occupational therapy (ergotherapy) for patients recovering from injuries, especially those covered by Germany’s statutory accident insurance (Berufsgenossenschaften, or BG). Its digital platform enables early, specialist-led therapy via video sessions, addressing complex conditions such as severe hand injuries, complex regional pain syndrome (CRPS), and amputee rehabilitation.
By focusing on the critical recovery period after accidents, Routine Health helps patients regain function faster while easing access to scarce therapy resources. The company has been profiled by regional health innovation programs as an example of how tele-therapies can complement traditional rehabilitation in Germany’s healthcare system.
Caspar Health
Founded: 2016 | Location: Berlin | Category: Digital rehabilitation and aftercare
Caspar Health offers a digital therapy platform used by rehabilitation clinics and hospitals to deliver remote aftercare and therapy programs. Its software supports physiotherapy, occupational therapy, and psychological care, enabling patients to continue treatment at home after inpatient rehab.
More than 160 hospitals across Germany use Caspar, and the platform has been validated in collaborations with the German Pension Insurance (DRV), which recognizes digital aftercare as equivalent to conventional programs. In 2021, Caspar raised €9 million to expand its hospital partnerships and further develop its product.
Kaia Health
Founded: 2016 | Location: Munich | Category: Digital therapeutics for MSK and COPD
Kaia Health develops app-based digital therapeutics for musculoskeletal (MSK) disorders and chronic obstructive pulmonary disease (COPD). Its programs combine physiotherapy, behavioral training, and education, supported by AI-driven exercise feedback.
Kaia has published peer-reviewed clinical trials and real-world studies demonstrating reduced pain and cost savings compared to standard care. In 2021, the company raised a $75 million Series C led by SoftBank Vision Fund 2, one of the largest healthtech rounds in Germany, to expand across Europe and the U.S.
Nilo Health
Founded: 2019/2020 | Location: Berlin/Munich | Category: Workforce mental health
Nilo Health provides a digital platform for employee mental health support, combining access to licensed therapists with coaching and self-guided digital programs. Companies purchase Nilo as a benefit for their teams, giving employees confidential access to therapy sessions and tools for stress, anxiety, and burnout prevention.
In 2022, Nilo raised $8 million in a funding round led by Speedinvest and PROfounders Capital to scale its services across Europe. Its platform now operates in multiple languages, serving global teams and helping employers address growing mental health needs in the workplace. Nilo Health reflects Germany’s role in building clinically robust, employer-facing digital care solutions that are exportable across Europe.
SmartPatient (creator of MyTherapy)
Founded: 2012 | Location: Munich | Category: Medication management and patient support
SmartPatient operates MyTherapy, a medication-management and patient-support app used by more than 12 million users in over 30 languages. The platform supports pharma companies by enabling patient support programs (PSPs), digital companions, and SaMD (software as a medical device) extensions.
In a 2024 partnership with Merck KGaA, SmartPatient expanded its use into cardiovascular disease, building on existing experience in chronic disease management. The company was acquired by Shop Apotheke Europe (now Redcare Pharmacy) in 2021, giving it more resources to scale both consumer engagement and industry-facing services.
Zanadio (by Aidhere)
Founded: 2019 | Location: Hamburg | Category: Obesity digital therapeutic (DiGA)
Zanadio is a prescription digital therapeutic for obesity (BMI 30–40 ) listed permanently in Germany’s DiGA directory. It has been prescribed over 50,000 times by more than 10,000 doctors. After 12 months of use, the product reports average weight loss of about 8%, representing a long-term behavioral change in users.
Sidekick Health acquired its parent company, Aidhere, in October 2023, bringing Zanadio under its global prescription digital therapeutics (PDT) portfolio. The acquisition underscores Zanadio’s status as one of Germany’s most successful DiGAs in obesity care.
Dermanostic
Founded: 2019 | Location: Solingen | Category: Tele-dermatology
Dermanostic offers an app-based dermatology service where patients upload photos and answer a brief questionnaire, then receive a specialist diagnosis, treatment plan, and prescription within 24 hours. The company reports treating more than 300,000 patients with a 98% recommendation rate and an average response time of around six hours.
In July 2025, it raised €4 million to expand across Germany and Europe, building on earlier strategic investment from Beiersdorf’s OSCAR&PAUL VC unit in 2022. Regulatory oversight has been active: a modified version of its app recently cleared a legal challenge in Hamburg, underscoring the scrutiny facing telemedicine providers. Dermanostic illustrates how specialty telehealth models are scaling in Germany by combining physician-led care with consumer-friendly access.
Signals for Investors: What These Startups Reveal
Germany shows early strength in digital therapeutics
Companies such as Cara Care, HelloBetter, Kaia Health, and Zanadio indicate how the DiGA pathway can support regulated apps in becoming prescribable and reimbursed, even though broad adoption and commercial success remain uneven.
Clinical validation appears to be a key driver
Startups like Noah Labs, Caspar Health, and Heartbeat Medical suggest that evidence generation and hospital or insurer partnerships are often critical to gaining traction in the German market.
Specialist telemedicine may be gaining ground
Wellster, Formel Skin, and Dermanostic reflect how narrowly focused telemedicine models — particularly in dermatology and weight management — are showing signs of growth through both consumer demand and payer interest.
Data and infrastructure platforms are finding wider uses
Ada Health, XO Life, and SmartPatient illustrate how German startups are beginning to supply data-driven solutions that appeal not only to local healthcare providers but also to pharma and international partners.
Final Thoughts on Digital Health Startups in Germany
Germany offers a distinctive combination of market scale, regulatory structure, and research depth that makes it an important environment for digital health innovation. The DiGA pathway has created opportunities for software-based therapeutics, though adoption has shown that reimbursement alone does not guarantee long-term success. Insurer relationships, clinical validation, and careful scaling strategies appear to play a central role.
For investors and founders, Germany may provide lessons on how regulated digital health products can enter mainstream care and where the challenges of commercial adoption lie. It is also a market that could serve as a launch point for broader European expansion, and entry into the US, particularly for companies with strong evidence bases and payer alignment.
Check out our other roundups on digital health startups in the UK, India, the Middle East, and Canada.
